Analytical Data
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基因名
AGXT2
- Application
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别名
AGXT2；AGT2；Alanine--glyoxylate aminotransferase 2. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BYV1
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表达区间
42-514aa
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氨基酸序列
LHTKPRMPP CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK GFLKEAFELV RARGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK GIGNGFPMAA VITTPEIAKS LAKCLQHFNT FGGNPMACAI GSAVLEVIKE ENLQENSQEV GTYMLLKFAK LRDEFEIVGD VRGKGLMIGI EMVQDKISCR PLPREEVNQI HEDCKHMGLL VGRGSIFSQT FRIAPSMCIT KPEVDFAVEV FRSALTQHME RRAK
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分子量
57.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AGXT2 (Alanine-Glyoxylate Aminotransferase 2) is an important enzyme involved in the metabolism of amino acids and the detoxification of glyoxylate, a byproduct of various metabolic pathways. Its role in converting glyoxylate to glycine helps to mitigate potential toxicity, particularly in the liver and kidneys. Mutations in the AGXT2 gene have been linked to specific metabolic disorders, including hyperoxaluria and primary hyperoxaluria type 2, which can lead to kidney stones and renal failure. Research on AGXT2 recombinant protein aims to better understand its structure, function, and the effects of specific mutations on its enzymatic activity. This knowledge is crucial for developing potential therapeutic strategies for metabolic disorders associated with AGXT2 deficiencies. Additionally, studying AGXT2 can provide insights into the broader mechanisms of amino acid metabolism and its implications in human health. Recombinant AGXT2 proteins produced in various expression systems allow for characterizing the enzyme's biochemical properties and exploring potential applications in gene therapy or enzyme replacement therapy. Thus, the study of AGXT2 not only enhances our understanding of metabolic pathways but also paves the way for innovative approaches to treat related disorders.
