Analytical Data
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基因名
PIM1
- Application
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别名
PIM1;Serine/threonine-Protein kinase pim-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11309-2
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表达区间
38-290aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MYQVGPLLGS GGFGSVYSGI RVSDNLPVAI KHVEKDRISD WGELPNGTRV PMEVVLLKKV SSGFSGVIRL LDWFERPDSF VLILERPEPV QDLFDFITER GALQEELARS FFWQVLEAVR HCHNCGVLHR DIKDENILID LNRGELKLID FGSGALLKDT VYTDFDGTRV YSPPEWIRYH RYHGRSAAVW SLGILLYDMV CGDIPFEHDE EIIRGQVFFR QRVSSECQHL IRWCLALRPS DRPTFEEIQN HPWM
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIM1, a member of the PIM (Proviral Integration site in Moloney murine leukemia virus) kinase family, has garnered significant attention in cancer research due to its role in promoting cell survival, proliferation, and tumorigenesis. Elevated expression of PIM1 has been linked to various malignancies, including hematological cancers and solid tumors, making it a potential target for therapeutic intervention. The PIM1 kinase functions by phosphorylating several key substrates involved in critical cellular processes, such as the regulation of apoptosis and cell cycle progression. Research into recombinant PIM1 protein focuses on elucidating its precise mechanisms of action, its interaction with other signaling pathways, and potential as a therapeutic target. Producing recombinant PIM1 allows researchers to study its biochemical properties, enzyme kinetics, and the effects of specific inhibitors. Such studies contribute to our understanding of its oncogenic role and pave the way for developing PIM1-targeted therapies, ultimately leading to novel treatment strategies for cancers with overactive PIM1 signaling. The comprehensive exploration of PIM1 through recombinant technology is essential for advancing cancer therapeutics and enhancing patient outcomes.
