Analytical Data
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基因名
PIH1D1
- Application
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别名
PIH1D1;NOP17;PIH1 domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWS0
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表达区间
1-290aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMANPKLL GMGLSEAEAI GADSARFEEL LLQASKELQQ AQTTRPESTQ IQPQPGFCIK TNSSEGKVFI NICHSPSIPP PADVTEEELL QMLEEDQAGF RIPMSLGEPH AELDAKGQGC TAYDVAVNSD FYRRMQNSDF LRELVITIAR EGLEDKYNLQ LNPEWRMMKN RPFMGSISQQ NIRSEQRPRI QELGDLYTPA PGRAESGPEK PHLNLWLEAP DLLLAEVDLP KLDGALGLSL EIGENRLVMG GPQQLYHLDA YIPLQINSHE SKAAFHRKRK QLMVAMPLLP VPS
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIH1D1, a member of the PIH family of proteins, has gained significant attention in recent years due to its critical role in cellular processes, particularly in the context of protein folding and the maintenance of proteostasis. Understanding the molecular mechanisms underlying PIH1D1 function is essential, as it is implicated in various cellular pathways related to stress responses and adaptation. Research indicates that PIH1D1 interacts with the Hsp90 chaperone complex, suggesting its involvement in the maturation of client proteins and potential implications in cancers and neurodegenerative diseases. The recombinant expression of PIH1D1 provides valuable insight into its structural and functional properties, allowing researchers to explore its interaction dynamics with other molecular partners. This line of inquiry is vital for deciphering the broader biological roles of PIH1D1, paving the way for potential therapeutic applications. Given the importance of proteostasis in health and disease, elucidating the specific functions and regulatory mechanisms associated with PIH1D1 could ultimately contribute to the development of novel strategies for treating diseases characterized by protein misfolding and aggregation. This research not only enhances our understanding of cellular physiology but also underscores the potential of targeting PIH1D1 in clinical interventions.
