Analytical Data
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Gene name
METTL8
- Application
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Alternative Names
METTL8mRNA N(3)-methylcytidine methyltransferase METTL8; EC 2.1.1.-; Methyltransferase-like protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H825
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Expression Region
1-291 aa
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AA Sequence
MNMIWRNSIS CLRLGKVPHR YQSGYHPVAP LGSRILTDPA KVFEHNMWDH MQWSKEEEAA ARKKVKENSA VRVLLEEQVK YEREASKYWD TFYKIHKNKF FKDRNWLLRE FPEILPVDQK PEEKARESSW DHVKTSATNR FSRMHCPTVP DEKNHYEKSS GSSEGQSKTE SDFSNLDSEK HKKGPMETGL FPGSNATFRI LEVGCGAGNS VFPILNTLEN SPESFLYCCD FASGAVELVK SHSSYRATQC FAFVHDVCDD GLPYPFPDGI LDVILLVFVL SSIHPDRTLF I
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Molecular Weight
33.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
METTL8, a member of the RNA methyltransferase family, has garnered attention in recent years due to its potential role in regulating gene expression and cellular processes through RNA modifications. As a methyltransferase that specifically targets adenosine residues in RNA, METTL8 may influence various physiological and pathological outcomes, including cell differentiation, proliferation, and stress responses. Given the growing evidence linking RNA methylation to critical biological functions and disease mechanisms, researchers are keen to elucidate the exact biochemical pathways and molecular interactions involving METTL8. Initial studies suggest its involvement in cancer progression and immune responses, highlighting the need for further investigation into its enzymatic activity, substrate specificity, and potential as a therapeutic target. Understanding the functional implications of METTL8 and its reactivity in different cellular contexts could provide insights into RNA metabolism and lead to novel strategies for modulating gene expression in diseases where RNA methylation plays a crucial role. Thus, the study of METTL8 contains significant promise for advancing our knowledge of RNA biology and therapeutic developments in oncology and beyond.
