Analytical Data
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基因名
ABCB8
- Application
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别名
ABCB8；MABC1；MITOSUR；Mitochondrial potassium channel ATP-binding subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NUT2
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表达区间
38-693aa
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氨基酸序列
GKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSA WCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLF WQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSF MTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLR QDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEA LGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFN CMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVR GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRD LRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAARE ANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDE ATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRV WEAGTH
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分子量
87 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCB8 is a member of the ATP-binding cassette (ABC) transporter family, specifically known for its role in the mitochondrial inner membrane. The protein is primarily involved in the transport of various substrates, including metabolites and ions, which are crucial for maintaining mitochondrial function and cellular homeostasis. Research into ABCB8 has gained traction due to its implications in various physiological processes and its potential connections to health and disease. Notably, mutations or dysregulation of ABCB8 have been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, highlighting its importance in cellular metabolism and energy production. Understanding the structure, function, and regulation of ABCB8 can provide insights into its role in mitochondrial dynamics and its potential as a therapeutic target. Advances in techniques such as crystallography and cryo-electron microscopy have enabled researchers to explore the detailed mechanisms by which ABCB8 operates at the molecular level, further emphasizing the need for comprehensive studies on this intriguing protein.
