Analytical Data
-
Gene name
METTL6
- Application
-
Alternative Names
METTL6tRNA N(3)-methylcytidine methyltransferase METTL6; EC 2.1.1.-; Methyltransferase-like protein 6
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8TCB7
-
Expression Region
1-284 aa
-
AA Sequence
MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK RNSTNFFKDR HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE DPNIFAYACD FSPRAIEYVK QNPLYDTERC KVFQCDLTKD DLLDHVPPES VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK PGKSVLFRDY GLYDHAMLRF KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV NEYVFRETVN KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS
-
Molecular Weight
33.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
METTL6 (Methyltransferase-like 6) is a recently identified protein that is part of the methyltransferase family, which plays a significant role in various biological processes, including RNA methylation and gene expression regulation. The study of METTL6 is particularly relevant due to its implications in cellular function and potential links to diseases, including cancer and neurological disorders. It is believed that METTL6 modifies mRNA and other RNA molecules by adding methyl groups, thus influencing RNA stability, splicing, and translation. Research has shown that aberrant expression of METTL6 can disrupt normal cellular pathways, making it a potential biomarker for certain diseases. Additionally, as the understanding of RNA modifications expands, elucidating the specific functions and mechanisms of METTL6 could uncover novel therapeutic targets, providing insights into RNA biology and its regulatory networks. The ongoing research into METTL6 recombinant proteins aims to further dissect its functional roles in cellular physiology and pathology, contributing to the broader field of epitranscriptomics where RNA modifications are recognized as critical regulators of gene expression. Understanding METTL6's structure and function at a molecular level is essential for developing targeted strategies that may ameliorate diseases linked to its dysregulation.
