Analytical Data
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基因名
METTL2B
- Application
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别名
METTL2BtRNA N(3)-methylcytidine methyltransferase METTL2B; EC 2.1.1.-; Methyltransferase-like protein 2B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P1Q9
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表达区间
2-378 aa
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氨基酸序列
AGSYPEGAP AILADKRQQF GSRFLSDPAR VFHHNAWDNV EWSEEQAAAA ERKVQENSIQ RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF PELAPSQNQN HLKDWFLENK SEVCECRNNE DGPGLIMEEQ HKCSSKSLEH KTQTPPVEEN VTQKISDLEI CADEFPGSSA TYRILEVGCG VGNTVFPILQ TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL CDEEKSYPVP KGSLDIIILI FVLSAVVPDK MQKAINRLSR LLKPGGMVLL RDYGRYDMAQ LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL QVNRGKQLTM YRVWIQCKYC KPLLSSTS
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分子量
43,4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METTL2B, a member of the methyltransferase family, has garnered attention in recent years due to its potential role in RNA methylation and gene regulation. Research has indicated that METTL2B may influence various biological processes, including cell differentiation, proliferation, and response to stress. Given its involvement in methylation, it is hypothesized that METTL2B can affect mRNA stability and translation, contributing to the fine-tuning of gene expression. Dysregulation of this protein has been implicated in several diseases, including cancer, where altered methylation patterns can drive oncogenic pathways. Consequently, generating recombinant METTL2B protein is pivotal for elucidating its biochemical functions and understanding its role in cellular processes. Through structural and functional analyses of the recombinant protein, researchers aim to explore the mechanisms by which METTL2B interacts with RNA substrates and other cellular factors. This could provide insights into potential therapeutic targets for diseases linked to methylation dysregulation. As a result, the study of METTL2B and its recombinant protein forms an essential avenue for advancing our understanding of epitranscriptomics and its impact on health and disease.
