Analytical Data
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基因名
METTL17
- Application
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别名
False p73 target gene protein;Methyltransferase 11 domain-containing protein 1;Protein RSM22 homolog, mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H7H0
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表达区间
20-456 aa
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氨基酸序列
VAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES
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分子量
54.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METTL17, a member of the methyltransferase-like family, has garnered significant interest in recent years due to its role in cellular processes such as RNA methylation and regulation of gene expression. This protein is known to modify adenosine residues in RNA, influencing stability and translation efficiency, which can have profound implications for cellular function and organismal development. Research indicates that aberrant METTL17 activity may be linked to various diseases, including cancer and neurodegenerative disorders, underscoring the need for detailed studies on its mechanism of action. To facilitate these investigations, the production of recombinant METTL17 proteins is crucial. This enables researchers to obtain pure and functional protein for in vitro studies and structural analysis. These studies can provide insights into the enzymatic properties of METTL17, identify potential interacting partners, and elucidate its biological pathways. Moreover, understanding the precise role of METTL17 in RNA modification could open avenues for therapeutic interventions aimed at diseases associated with its dysregulation. As a result, the characterization of recombinant METTL17 is a pivotal step in advancing our knowledge of its functions and therapeutic potential in the context of health and disease.
