Analytical Data
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基因名
ABCE1
- Application
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别名
ABCE1；RLI；RNASEL1；RNASELI；ATP-binding cassette sub-family E member 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61221
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表达区间
1-599aa
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氨基酸序列
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
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分子量
67.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCE1 (ATP-Binding Cassette Sub-Family E Member 1) is an essential protein that plays a critical role in various cellular processes, including translation regulation and viral replication. As a member of the ATP-binding cassette (ABC) transporter family, ABCE1 is unique in its dual functionality; it not only transports molecules across membranes but also interacts with ribosomes and influences protein synthesis. Research has increasingly focused on ABCE1 due to its implications in health and disease. Studies have demonstrated that ABCE1 is involved in the innate immune response, facilitating the translation of specific mRNAs in response to viral infections, making it a potential target for antiviral therapies. Furthermore, dysregulation of ABCE1 has been linked to cancer biology, where it might affect the ability of cells to regulate growth and apoptosis. Understanding the structural and functional properties of ABCE1, particularly through the study of its recombinant forms, provides valuable insights into its mechanistic roles and potential therapeutic applications. Techniques such as X-ray crystallography and cryo-electron microscopy are being employed to elucidate its structure, while functional assays are advancing our knowledge of its interactions at the molecular level. Collectively, this research paves the way for harnessing ABCE1 as a biomarker or a molecular target in various diseases, emphasizing the importance of continued exploration in the field of recombinant protein studies.
