Analytical Data
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基因名
GJA5
- Application
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别名
GJA5；Gap junction alpha-5 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36382
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表达区间
1-358aa
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氨基酸序列
MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGSGSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV
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分子量
41.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJA5, a gene encoding the gap junction protein connexin 40, plays a crucial role in cellular communication, particularly in the cardiovascular system. Its expression is primarily observed in the heart, where it facilitates intercellular electrical coupling, impacting cardiac conduction and rhythm. Dysregulation or mutations in GJA5 have been linked to various cardiac disorders, including atrial fibrillation and other arrhythmias, making it a significant target for cardiovascular research. The study of GJA5 recombinant proteins is particularly important for understanding the molecular mechanisms underlying these conditions. By generating and analyzing GJA5 recombinant proteins, researchers can investigate the protein's structure, function, and interaction with other cellular components. This research can provide insights into the role of GJA5 in normal and pathological cardiac physiology, paving the way for potential therapeutic strategies targeting gap junction communication. Moreover, exploring the post-translational modifications and functional states of GJA5 can shed light on how environmental factors and genetic variations impact its activity, further advancing our understanding of heart health and disease.
