Analytical Data
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基因名
OSBP
- Application
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别名
OSBP;OSBP1;Oxysterol-binding Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22059
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表达区间
324-407aa
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氨基酸序列
GATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLG HKRTGSNISGASSDISLDEQYKHQLEETKKEKRT
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSBP (Oxysterol-Binding Protein) is a pivotal player in cellular lipid metabolism and signaling, functioning as a lipid sensor that interacts with oxysterols, a class of bioactive lipids derived from cholesterol. Research into OSBP has gained momentum due to its critical role in regulating the transport of lipids between cellular organelles, specifically the endoplasmic reticulum and the Golgi apparatus, thereby influencing various cellular processes including membrane biogenesis, cell proliferation, and apoptosis. OSBP also serves as an important mediator in the response to cellular stress and has been implicated in several pathological conditions, such as cardiovascular diseases and cancer, highlighting its potential as a therapeutic target. The study of OSBP recombinant proteins has provided valuable insights into its molecular mechanisms and interactions with other proteins and lipids. By elucidating the structural and functional aspects of OSBP, researchers aim to uncover the complexities of lipid metabolism and develop novel strategies for intervention in diseases associated with dysregulated lipid homeostasis. The development of recombinant OSBP proteins facilitates a better understanding of their biochemical properties, enabling the exploration of their role in cellular signaling pathways and overall lipid management within the cell. As such, the research on OSBP and its recombinant proteins is vital for advancing our understanding of lipid biology and its implications in health and disease.












