Analytical Data
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基因名
MBOAT2
- Application
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别名
1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; LPAAT; LPCAT4; LPEAT; LPLAT 2; Lyso-PA acyltransferase; Lyso-PE acyltransferase; Lysophosphatidic acid acyltransferase; Lysophosphatidylethanolamine acyltransferase; Lysophospholipid acyltransferase 2; MBOA2_HUMAN; Mboat2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZWT7
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表达区间
1-350aa
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氨基酸序列
MPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ
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分子量
66.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MBOAT2 (Membrane-Bound O-acyltransferase 2) is a critical enzyme involved in the post-translational modification of proteins through palmitoylation, a process that impacts membrane localization and protein stability. Research on MBOAT2 has gained attention due to its potential implications in various physiological processes and its association with various diseases, including cancer and neurodegenerative disorders. This interest is heightened by the recognition that palmitoylation can significantly influence cellular signaling pathways, affecting cell growth, movement, and apoptosis. Understanding the structural and functional aspects of MBOAT2, particularly through the study of its recombinant protein, is pivotal for elucidating its role in disease mechanisms and cellular functions. Furthermore, MBOAT2's involvement in the regulation of lipid metabolism and membrane dynamics positions it as a potential therapeutic target. By producing recombinant MBOAT2, researchers aim to study its enzymatic activity, interactions with substrates, and regulatory mechanisms in detail, advancing our knowledge of its biological significance and paving the way for potential interventions in related pathologies. This area of research not only facilitates a deeper understanding of lipid metabolism but also enhances our ability to design specific inhibitors or modulators that could be beneficial in clinical settings.
