Analytical Data
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Gene name
PAIP2
- Application
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Alternative Names
PAIP2;PAIP2A;Polyadenylate-binding Protein-interacting Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BPZ3
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Expression Region
1-127aa
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AA Sequence
MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKYGNI
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Molecular Weight
21.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAIP2 (Poly(A)-binding protein interacting protein 2) has emerged as a critical regulator in the realm of gene expression and mRNA stability. This protein interacts with the poly(A)-binding protein (PABP), influencing the translation and degradation of mRNA in eukaryotic cells. Researchers have focused on PAIP2 due to its pivotal role in post-transcriptional regulation, which is essential for various cellular processes, including cell proliferation and differentiation. Dysregulation of PAIP2 has been implicated in several diseases, including cancer, where abnormal mRNA metabolism can lead to uncontrolled cell growth. By studying PAIP2, scientists aim to elucidate its mechanisms of action and therapeutic potential. Additionally, PAIP2 serves as a crucial player in the interplay between mRNA and microRNA pathways, further underscoring its importance in maintaining cellular homeostasis. Recent advances in structural biology and biochemistry have provided insights into the functional domains of PAIP2 and its interactions with other molecular partners, setting the stage for potential drug development targeting its pathway. Understanding PAIP2's role could pave the way for novel strategies in cancer treatment and other disorders linked to mRNA dysregulation. Thus, ongoing research into PAIP2 not only enhances our comprehension of fundamental biological processes but also offers hope for new therapeutic interventions in diseases characterized by aberrant gene expression.
