Analytical Data
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基因名
PTPRF
- Application
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别名
PTPRF；LAR；Receptor-type tyrosine-Protein phosphatase F
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10586
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表达区间
1275-1897aa
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氨基酸序列
ILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTP GMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEV NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQ GPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGL IQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPT PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTV DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHI QKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIM PYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHK TKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTL RTQRPAMVQTEDQYQLCYRAALE
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分子量
93 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPRF (Protein Tyrosine Phosphatase Receptor Type F) is a member of the protein tyrosine phosphatase (PTP) family, which plays a critical role in cellular signaling by removing phosphate groups from tyrosine residues on proteins. This function is essential for the regulation of various cellular processes, including growth, differentiation, and immune response. Dysregulation of PTPs has been implicated in numerous diseases, including cancer and autoimmune disorders. Due to its role in these pathological conditions, PTPRF has garnered attention as a potential therapeutic target. Researchers are increasingly interested in producing recombinant PTPRF proteins to study their structure, function, and interactions with other cellular components. The generation of recombinant PTPRF not only allows for the elucidation of its biochemical properties but also facilitates high-throughput screening of potential inhibitors or activators that could be used in clinical applications. Recent advances in recombinant DNA technology and protein expression systems have enabled more efficient production of this protein in sufficient quantities for various biochemical assays. Understanding the functional mechanisms of PTPRF through recombinant studies can provide insights into its role in health and disease, paving the way for novel approaches in disease treatment and drug development. As such, ongoing research efforts aim to unravel the complexities of PTPRF signaling pathways and their implications in human health, making it a focal point in molecular biology and therapeutic innovation.
