Analytical Data
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基因名
KIF18B
- Application
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别名
KIF18B；Kinesin-like Protein KIF18B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86Y91
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表达区间
1-355aa
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氨基酸序列
MAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSL
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分子量
46.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIF18B is a member of the kinesin superfamily of motor proteins, primarily involved in intracellular transport and mitotic functions. It plays a crucial role in the regulation of microtubule dynamics during cell division, particularly in the positioning and movement of mitotic chromosomes. Dysregulation of KIF18B has been associated with various cancers, highlighting its potential as a therapeutic target. Recent studies have focused on the recombinant expression of KIF18B to elucidate its structural and functional properties. By producing recombinant KIF18B protein in heterologous systems, researchers aim to investigate the mechanistic details of its motor function and its role in mitosis. Understanding the interactions between KIF18B and other cellular components, such as microtubules and various regulatory proteins, can provide insights into its function in normal cellular processes and its implications in disease. Additionally, the recombinant form of KIF18B can be utilized in biochemical assays to screen for potential inhibitors or modulators, paving the way for novel cancer therapies. This research area is crucial for advancing our understanding of motility within cells and the cellular mechanisms underlying tumorigenesis.
