Analytical Data
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基因名
HPS1
- Application
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别名
HPS1；HPS；BLOC-3 complex member HPS1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92902
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表达区间
1-324aa
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氨基酸序列
MKCVLVATEGAEVLFYWTDQEFEESLRLKFGQSENEEEELPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNFLYVLHLFGECLFIAINGDHTESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKELRPPDLAQRVQLWEHFQSLLWTYSRLREQEQCFAVEALERLIHPQLCELCIEALERHVIQAVNTSPERGGEEALHAFLLVHSKLLAFYSSHSASSLRPADLLALILLVQDLYPSESTAEDDIQPSPRRARSSQNIPVQQAWSPHSTGPTGGSSAETETDSFSLPEEYFTPAPSPGDQSSGEDRRKAGGNNS
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分子量
63.5kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HPS1, or Hermansky-Pudlak Syndrome 1, is a gene associated with a rare genetic disorder characterized by oculocutaneous albinism, bleeding disorders, and lung and gut diseases due to lysosomal dysfunction. This syndrome is caused by mutations in the HPS1 gene, which plays a crucial role in the biogenesis of lysosome-related organelles, particularly in melanosomes and platelet dense granules. The study of HPS1 recombinant proteins is essential for understanding the molecular mechanisms underlying this syndrome, as well as for developing potential therapeutic strategies. By producing and studying HPS1 recombinant proteins, researchers aim to elucidate the protein's structure, interactions, and functionality within cellular pathways. This research can provide insights into the pathophysiology of Hermansky-Pudlak Syndrome and identify possible interventions to ameliorate the symptoms associated with the disorder. Furthermore, understanding HPS1's role in lysosome-related organelle function may contribute to broader knowledge of lysosomal storage diseases and other related conditions. As an emerging field of study, the investigation of HPS1 and its recombinant proteins holds promise for advancing both basic and translational research in genetics and molecular biology.
