Analytical Data
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Gene name
SNRPD1
- Application
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Alternative Names
SNRPD1；SNRPD1；Small nuclear ribonucleoProtein Sm D2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62314
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Expression Region
1-119aa
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AA Sequence
MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR
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Molecular Weight
13.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNRPD1, a crucial component of the spliceosomal machinery, plays a vital role in pre-mRNA splicing by forming part of the small nuclear ribonucleoproteins (snRNPs). These snRNPs are essential for the removal of introns from precursor mRNAs, a process that is critical for the accurate expression of eukaryotic genes. Researchers have increasingly focused on SNRPD1 due to its implications in various cellular processes and its association with certain diseases, including cancer and genetic disorders. The study of SNRPD1 recombinant protein allows for in-depth analysis of its structure, function, and interaction with other spliceosomal components, which can provide insights into splicing mechanisms. Additionally, the production of SNRPD1 as a recombinant protein facilitates the development of potential therapeutic strategies aimed at modulating splicing for disease intervention. This research area is particularly significant given the emerging recognition of alternative splicing as a major regulatory mechanism affecting gene expression and cellular function. Investigating SNRPD1 not only enhances our understanding of fundamental cellular processes but may also lead to novel therapeutic approaches for diseases linked to splicing dysfunction.
