Analytical Data
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基因名
NEUROG3
- Application
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别名
NEUROG3;ATOH5;BHLHA7;NGN3;Neurogenin-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y4Z2
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表达区间
1-214aa
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氨基酸序列
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
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分子量
30.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NEUROG3, also known as neurogenin 3, is a crucial transcription factor involved in the development of neuroendocrine cells, particularly in the pancreas. Its significance lies in the regulation of pancreatic endocrine differentiation, which is central to maintaining glucose homeostasis through insulin secretion. Dysregulation of NEUROG3 has been implicated in various metabolic disorders, including diabetes. Recent studies have focused on the potential therapeutic applications of NEUROG3, particularly in regenerative medicine, as its expression can drive the generation of insulin-producing beta cells from pluripotent stem cells. Understanding the mechanisms governing NEUROG3 function and its role in cell differentiation can provide insights into novel interventions for diabetes treatment and regenerative therapies. Additionally, the recombinant protein form of NEUROG3 is being utilized in research to elucidate its functional roles and interactions with other signaling pathways. This line of investigation is crucial for developing targeted strategies to promote the regeneration of pancreatic islets and enhance beta cell function, presenting a promising avenue for future diabetes therapies.
