Analytical Data
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基因名
F2RL2
- Application
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别名
F2RL2；PAR3；Proteinase-activated receptor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00254
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表达区间
39-374aa
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氨基酸序列
TFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
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分子量
40.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
F2RL2, also known as protease-activated receptor 2 (PAR2), is a G-protein-coupled receptor that plays a crucial role in various physiological and pathological processes, including inflammation, pain sensation, and immune response. The activation of F2RL2 occurs through proteolytic cleavage by serine proteases, such as thrombin, which allows it to interact with different intracellular signaling pathways. The significance of F2RL2 in mediating inflammatory responses has prompted extensive research into its potential as a therapeutic target for various diseases, including asthma, arthritis, and cancer. Recombinant proteins of F2RL2 have been developed to facilitate the study of its structure and function, enabling researchers to explore the mechanistic details of receptor activation and downstream signaling. These recombinant proteins are essential for high-throughput screening of potential agonists and antagonists, providing valuable insights into drug development. Additionally, understanding F2RL2's role in cellular signaling can contribute to the design of novel therapeutic strategies aimed at modulating its activity for the treatment of chronic inflammatory diseases, pain management, and other conditions where abnormal PAR2 signaling is implicated. Overall, the study of F2RL2 and its recombinant forms is crucial for advancing our understanding of its biological functions and therapeutic potential.
