Analytical Data
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Gene name
F2RL2
- Application
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Alternative Names
F2RL2；PAR3；Proteinase-activated receptor 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00254
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Expression Region
39-374aa
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AA Sequence
TFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
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Molecular Weight
40.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
F2RL2, also known as protease-activated receptor 2 (PAR2), is a G-protein-coupled receptor that plays a crucial role in various physiological and pathological processes, including inflammation, pain sensation, and immune response. The activation of F2RL2 occurs through proteolytic cleavage by serine proteases, such as thrombin, which allows it to interact with different intracellular signaling pathways. The significance of F2RL2 in mediating inflammatory responses has prompted extensive research into its potential as a therapeutic target for various diseases, including asthma, arthritis, and cancer. Recombinant proteins of F2RL2 have been developed to facilitate the study of its structure and function, enabling researchers to explore the mechanistic details of receptor activation and downstream signaling. These recombinant proteins are essential for high-throughput screening of potential agonists and antagonists, providing valuable insights into drug development. Additionally, understanding F2RL2's role in cellular signaling can contribute to the design of novel therapeutic strategies aimed at modulating its activity for the treatment of chronic inflammatory diseases, pain management, and other conditions where abnormal PAR2 signaling is implicated. Overall, the study of F2RL2 and its recombinant forms is crucial for advancing our understanding of its biological functions and therapeutic potential.
