Analytical Data
-
Gene name
LPAR5
- Application
-
Alternative Names
LPAR5; GPR92; GPR93; Lysophosphatidic acid receptor 5; LPA receptor 5; LPA-5; G-protein coupled receptor 92; G-protein coupled receptor 93
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9H1C0
-
Expression Region
1-372aa
-
AA Sequence
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
-
Molecular Weight
41.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LPAR5, or Lysophosphatidic Acid Receptor 5, is a member of the G-protein-coupled receptor family, which plays a crucial role in various physiological and pathological processes, including cell proliferation, migration, and survival. Recent studies have highlighted its significant involvement in cancer progression and metastasis, as well as in inflammatory responses and neurodegenerative diseases. The interest in LPAR5 as a therapeutic target has surged due to its potential to modulate such diverse biological effects. To better understand its structure-function relationships, researchers have focused on characterizing recombinant LPAR5 proteins, allowing for detailed studies of receptor signaling, ligand binding, and interactions with downstream effectors. This research is pivotal not only for elucidating the role of LPAR5 in disease mechanisms but also for developing novel strategies for pharmacological intervention. By creating and studying recombinant LPAR5 proteins, scientists can investigate conformational changes, determine binding affinities for different ligands, and explore the receptor's signaling pathways. Such efforts may pave the way for the design of selective modulators that could potentially serve as effective treatments for related diseases, making LPAR5 a promising candidate in the field of drug development.
