Analytical Data
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基因名
LPAR5
- Application
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别名
LPAR5; GPR92; GPR93; Lysophosphatidic acid receptor 5; LPA receptor 5; LPA-5; G-protein coupled receptor 92; G-protein coupled receptor 93
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H1C0
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表达区间
1-372aa
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氨基酸序列
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
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分子量
41.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LPAR5, or Lysophosphatidic Acid Receptor 5, is a member of the G-protein-coupled receptor family, which plays a crucial role in various physiological and pathological processes, including cell proliferation, migration, and survival. Recent studies have highlighted its significant involvement in cancer progression and metastasis, as well as in inflammatory responses and neurodegenerative diseases. The interest in LPAR5 as a therapeutic target has surged due to its potential to modulate such diverse biological effects. To better understand its structure-function relationships, researchers have focused on characterizing recombinant LPAR5 proteins, allowing for detailed studies of receptor signaling, ligand binding, and interactions with downstream effectors. This research is pivotal not only for elucidating the role of LPAR5 in disease mechanisms but also for developing novel strategies for pharmacological intervention. By creating and studying recombinant LPAR5 proteins, scientists can investigate conformational changes, determine binding affinities for different ligands, and explore the receptor's signaling pathways. Such efforts may pave the way for the design of selective modulators that could potentially serve as effective treatments for related diseases, making LPAR5 a promising candidate in the field of drug development.
