Analytical Data
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基因名
Cmklr1
- Application
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别名
Cmklr1；CHEMR23；DEZ；Chemerin-like receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99788
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表达区间
1-373aa
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氨基酸序列
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
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分子量
45.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cmklr1 (Chemokine-like receptor 1) is a G protein-coupled receptor that has garnered significant interest in the context of immune response and inflammatory diseases. Originally identified as a receptor that binds to specific chemokines, Cmklr1 plays a critical role in mediating cellular migration and tissue homeostasis. Research has shown that Cmklr1 is involved in various physiological processes, including the regulation of cytokine release, lymphocyte trafficking, and the modulation of immune cell responses. Abnormal expression or function of Cmklr1 has been implicated in several pathological conditions, such as autoimmune diseases, cancer, and chronic inflammation. The study of recombinant Cmklr1 protein is essential for elucidating its structural and functional properties, as well as for developing targeted therapeutic strategies. By producing and characterizing recombinant Cmklr1, researchers aim to uncover its specific ligand interactions, signaling pathways, and downstream effects. This information could pave the way for innovative approaches in treating conditions associated with dysregulated immune responses. Additionally, understanding the molecular mechanisms underlying Cmklr1's role in the immune system could lead to advancements in vaccine development and the design of novel immunomodulatory agents. Overall, the investigation of Cmklr1 as a recombinant protein represents a promising avenue for advancing our knowledge of chemokine signaling and its implications in health and disease.
