Analytical Data
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基因名
NDUFS5
- Application
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别名
NDUFS5;NADH dehydrogenase [ubiquinone] iron-sulfur Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43920
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表达区间
1-106aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMPFLDIQKRFGLNIDRWLTIQSGEQPY KMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAG TIRKQRDKLIKEGKYTPPPHHIGKGEPRP
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDUFS5, also known as NADH dehydrogenase (ubiquinone) Fe-S protein 5, is a crucial component of the mitochondrial respiratory chain, specifically part of complex I. This enzyme plays a pivotal role in cellular energy metabolism by facilitating the transfer of electrons from NADH to ubiquinone, thereby contributing to ATP production through oxidative phosphorylation. Mutations or deficiencies in NDUFS5 are associated with a spectrum of mitochondrial diseases that often manifest in neurological, muscular, and metabolic disorders. Researchers have been exploring NDUFS5 recombinant protein for its potential in understanding the enzymatic mechanisms of complex I dysfunction and for developing therapeutic strategies. By studying the structural and functional properties of NDUFS5, scientists aim to elucidate the pathophysiological effects of its defects and to identify biomarkers for disease diagnosis and progression. Additionally, the recombinant production of NDUFS5 enables high-throughput screening of small molecules that could serve as potential drug candidates, offering new avenues for the treatment of mitochondrial-related diseases. Overall, the study of NDUFS5 recombinant protein is not only vital for basic mitochondrial biology but also holds significant clinical implications in the development of targeted therapies for complex I-related disorders.
