Analytical Data
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基因名
NDUFA5
- Application
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别名
NDUFA5;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16718
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表达区间
1-116aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMAGVLKK TTGLVGLAVC NTPHERLRIL YTKILDVLEE IPKNAAYRKY TEQITNEKLA MVKAEPDVKK LEDQLQGGQL EEVILQAEHE LNLARKMREW KLWEPLVEEP PADQWKWPI
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分子量
16 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDUFA5, or NADH:ubiquinone oxidoreductase subunit A5, is a critical component of the mitochondrial respiratory chain, specifically involved in complex I (NADH dehydrogenase) activity. Research on NDUFA5 has gained significant interest due to its pivotal role in cellular energy metabolism and its association with various mitochondrial-related disorders. Mutations in the NDUFA5 gene have been linked to early-onset neurodegenerative diseases and mitochondrial dysfunctions, which underscores the importance of understanding its function and mechanisms. The development of recombinant NDUFA5 protein allows researchers to investigate the structural and functional properties of this protein, facilitating studies on its interactions with other mitochondrial components. Furthermore, the recombinant protein can be utilized in high-throughput screening for potential therapeutic compounds, offering insights into novel treatment strategies for mitochondrial diseases. By elucidating the biochemical pathways and regulatory mechanisms involving NDUFA5, researchers aim to uncover targets for intervention, contributing to a deeper understanding of mitochondrial biology and its implications on human health.
