Analytical Data
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基因名
SLC14A1
- Application
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别名
SLC14A1；HUT11；JK；RACH1；Urea transporter 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13336
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表达区间
1-389aa
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氨基酸序列
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
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分子量
48.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC14A1, also known as the solute carrier family 14 member 1, is a pivotal protein involved in the transport of urea across cell membranes, playing a crucial role in nitrogen metabolism and homeostasis. Research into SLC14A1 has gained prominence due to its implications in various physiological and pathological processes, including renal function, metabolic disorders, and certain hereditary diseases such as familial dysautonomia. Dysregulation of urea transport is linked to conditions like kidney disease and has been associated with complications such as hyperuremia. Understanding the structure and function of SLC14A1 is essential for elucidating its role in health and disease. Recombinant SLC14A1 proteins are valuable tools in these studies, allowing researchers to investigate the protein's transport mechanisms, kinetics, and interactions with other cellular components. By employing techniques like protein purification and crystallography, scientists aim to decipher the detailed operational framework of SLC14A1, which may pave the way for novel therapeutic approaches targeting diseases related to urea transport dysregulation. This burgeoning field of research highlights the importance of SLC14A1 not just as a transporter but also as a potential biomarker and therapeutic target in metabolic diseases, offering insights into enhancing patient management and treatment strategies.
