Analytical Data
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Gene name
LHX6
- Application
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Alternative Names
LHX 6; LHX 6.1; LHX6; LHX6.1; LHX6_HUMAN; LIM homeobox 6; LIM homeobox protein 6; LIM homeodomain protein 6.1; LIM/homeobox protein Lhx6; LIM/homeobox protein Lhx6.1; MGC119542; MGC119544; MGC119545; OTTHUMP00000064113; OTTHUMP00000064114
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UPM6
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Expression Region
1-363aa
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AA Sequence
MAQPGSGCKA TTRCLEGTAP PAMAQSDAEA LAGALDKDEG QASPCTPSTP SVCSPPSAAS SVPSAGKNIC SSCGLEILDR YLLKVNNLIW HVRCLECSVC RTSLRQQNSC YIKNKEIFCK MDYFSRFGTK CARCGRQIYA SDWVRRARGN AYHLACFACF SCKRQLSTGE EFGLVEEKVL CRIHYDTMIE NLKRAAENGN GLTLEGAVPS EQDSQPKPAK RARTSFTAEQ LQVMQAQFAQ DNNPDAQTLQ KLADMTGLSR RVIQVWFQNC RARHKKHTPQ HPVPPSGAPP SRLPSALSDD IHYTPFSSPE RARMVTLHGY IESQVQCGQV HCRLPYTAPP VHLKADMDGP LSNRGEKVIL FQY
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LHX6 (LIM homeobox 6) is a member of the LIM homeobox gene family, which plays a crucial role in developmental processes, particularly in the formation of the central nervous system and various endocrine tissues. Research on LHX6 has gained attention due to its essential functions in neurogenesis and its potential implications in neurological disorders and cancer. This protein is involved in the regulation of neuronal identity and has been implicated in the development of inhibitory GABAergic neurons in the brain. Moreover, dysregulation of LHX6 expression has been associated with various pathophysiological conditions, including schizophrenia and other neurodevelopmental disorders. In cancer biology, LHX6 may influence tumor progression and metastasis, making it a potential biomarker for diagnosis and a target for therapeutic intervention. The study of LHX6 recombinant protein focuses on elucidating its structural characteristics, functional interactions, and regulatory mechanisms, which can provide insights into its role in both normal and pathological states. By using recombinant techniques, researchers can produce LHX6 in a controlled environment, allowing for detailed biochemical and biophysical analyses, and paving the way for the development of LHX6-targeted therapies. Understanding the precise functions and pathways involving LHX6 is crucial for advancing our knowledge of developmental biology and disease mechanisms, ultimately leading to innovative treatment strategies.
