Analytical Data
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Gene name
LHX4
- Application
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Alternative Names
CPHD4; Gsh 4; Gsh4; Lhx4; LHX4_HUMAN; LIM Homeobox 4; LIM Homeobox gene 4; LIM homeobox protein 4; LIM/homeobox protein Lhx4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969G2
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Expression Region
1-390aa
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AA Sequence
MMQSATVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW HSSCLKCADC QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ VVRKAQDFVY HLHCFACIIC NRQLATGDEF YLMEDGRLVC KEDYETAKQN DDSEAGAKRP RTTITAKQLE TLKNAYKNSP KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGSSKQ EKESSAEDCG VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ TLRAMAGGPT SDISTGSSVG YPDFPTSPGS WLDEMDHPPF
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Molecular Weight
43.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LHX4 is a member of the LIM-homeobox (LHX) gene family, playing a crucial role in neuronal development and the regulation of various biological processes, including the formation of the hypothalamus and the development of pituitary hormones. Mutations in the LHX4 gene have been linked to congenital hypopituitarism, a condition characterized by inadequate hormone production, which can lead to growth and developmental disorders. Research on LHX4 recombinant proteins is vital for understanding its functional mechanisms and physiological roles, particularly in neuroendocrine regulation. By studying these proteins, scientists aim to elucidate the interactions between LHX4 and its target genes, as well as its involvement in cellular signaling pathways. The production of LHX4 recombinant proteins allows for detailed analysis through in vitro assays, facilitating investigations into disease models and potential therapeutic interventions. Additionally, understanding LHX4's structure and function may provide insights into its role in other neurodevelopmental disorders, thereby expanding the scope of research beyond congenital conditions. The ongoing study of LHX4 is integral to advancing our knowledge of genetic contributions to endocrine health and neurodevelopment, paving the way for novel strategies in diagnosing and treating hormone-related disorders.
