Analytical Data
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Gene name
RPS6Ka1
- Application
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Alternative Names
RPS6Ka1；BFGFR；CEK；FGFBR；Fibroblast growth factor receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15418
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Expression Region
1-735aa
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AA Sequence
MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS ILAQRRVRKL PSTTL
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Molecular Weight
82.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RPS6Ka1, also known as ribosomal protein S6 kinase alpha-1, is a pivotal serine/threonine kinase that plays a critical role in cellular signaling pathways, particularly those involved in growth, proliferation, and survival. It is a key downstream effector of the mTOR (mechanistic target of rapamycin) pathway, which is essential for translating nutrient availability and growth signals into cellular responses. Dysregulation of RPS6Ka1 has been implicated in various pathological conditions, including cancer, where it contributes to altered cell growth and metabolism. Research on RPS6Ka1 has increased in recent years, focusing on its role in these fundamental processes and its potential as a therapeutic target. Recombination and expression studies of RPS6Ka1 protein facilitate the understanding of its functional mechanisms and interactions within the cell. Investigating the biochemical properties, interaction partners, and regulatory mechanisms of RPS6Ka1 can provide valuable insights into how it influences cellular behavior and disease progression. This research could pave the way for novel strategies in targeting RPS6Ka1 in cancer therapy and other diseases associated with mTOR signaling dysregulation. Therefore, RPS6Ka1 not only represents a crucial element in understanding intracellular signaling but also holds potential for development into a therapeutic candidate aimed at managing diseases characterized by aberrant cell growth and proliferation.
