Analytical Data
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基因名
LCORL
- Application
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别名
LCoR-like protein; LCORL; LCORL_HUMAN; ligand dependent nuclear receptor corepressor like; Ligand-dependent nuclear receptor corepressor-like protein; MBLK1 related protein; MLR1; Transcription factor MLR1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N3X6
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表达区间
1-602aa
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氨基酸序列
MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC VGFESILEGL YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS DCIPSLDSSQ STPTEELSSQ GQSNTDKIEC QAENYLNALF RKKDLPQNCD PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ ENRNGSIGPS IVCKSIQMNQ AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS IKSEESSICD PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA LWARAQAERT EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES LQYETSNPTV QLKIPQLRVS SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA LQKLKNILPK QNKIECSGPV THSSVDSYFL HGDLSPLCLN SKNGTVDGTS ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG KMSVSKAQGI YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK PV
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分子量
66.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LCORL (LZR-1/LCOR-like) is a member of the liganded nuclear receptor family, which plays a crucial role in various biological processes, including gene regulation, cellular differentiation, and response to hormonal signaling. Studies have identified LCORL as a critical factor in the development and function of reproductive organs and bones. Notably, mutations in the LCORL gene have been associated with skeletal dysplasia and various reproductive disorders, making it a significant target for understanding developmental biology and potential therapeutic interventions. The recombinant protein of LCORL is essential for elucidating its structure-function relationship and exploring its interaction with other nuclear receptors. Additionally, producing LCORL as a recombinant protein allows researchers to investigate its biochemical properties and signaling pathways in vitro, providing valuable insights into its role in pathophysiological conditions. Overall, understanding the function and mechanisms of LCORL through recombinant protein research may reveal new avenues for treating disorders related to growth and reproduction, thus highlighting its importance in both basic and applied biomedical research.
