Analytical Data
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基因名
LCE1F
- Application
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别名
LCE1F; LEP6Late cornified envelope protein 1F; Late envelope protein 6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T754
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表达区间
1-118aa
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氨基酸序列
MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCCSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC
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分子量
39.93 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LCE1F, a member of the late cornified envelope (LCE) family, is a protein that plays a critical role in skin barrier function and the regulation of keratinocyte differentiation. Research has underscored its importance in the epidermal layer of the skin, where it contributes to the formation of the cornified envelope, a structure vital for maintaining the skin's integrity and hydration. Mutations or variations in the LCE1F gene have been linked to several skin disorders, including psoriasis and atopic dermatitis, indicating its potential as a biomarker for these conditions. The study of LCE1F recombinant protein is particularly relevant for developing therapeutic strategies aimed at enhancing skin barrier function and treating skin diseases. By understanding the functional mechanisms of LCE1F, researchers can explore its role in cellular processes such as apoptosis, inflammation, and immune response. Moreover, the characterization of LCE1F facilitates the development of novel cosmetic and dermatological products designed to improve skin health. Overall, LCE1F represents a meaningful target for both basic and translational research in dermatology, with implications for the design of effective treatments for skin-related ailments.
