Analytical Data
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基因名
LCE1C
- Application
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别名
LCE1C; LEP3Late cornified envelope protein 1C; Late envelope protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T751
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表达区间
1-118aa
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氨基酸序列
MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC
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分子量
39.93 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LCE1C, a member of the late cornified envelope (LCE) family, is primarily expressed in the outer layers of the epidermis and plays a crucial role in skin barrier function and integrity. The LCE gene cluster is known for its contribution to keratinocyte differentiation and is thought to be involved in the skin's response to environmental stressors. Mutations and variations in the LCE1C gene have been associated with various dermatological conditions, including psoriasis and atopic dermatitis, highlighting its significance in skin health. Recent studies have focused on the recombinant production of LCE1C to investigate its structural and functional properties, which aids in understanding its role in skin biology and-pathology. The recombinant protein serves as a valuable tool for exploring the molecular mechanisms underlying skin barrier dysfunction and provides a basis for potential therapeutic applications. By using techniques such as protein expression and purification methods, researchers aim to elucidate the interaction of LCE1C with other skin proteins and its role in cell signaling pathways. Furthermore, understanding the immunological aspects of LCE1C through recombinant approaches could lead to the development of novel biomarker strategies for diagnosing and monitoring skin diseases. Overall, ongoing research on LCE1C recombinant protein presents a promising avenue for advancing skin science and developing new therapeutic options for skin-related disorders.
