Analytical Data
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Gene name
LBR
- Application
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Alternative Names
DHCR 14B; DHCR14B; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LBR; LBR_HUMAN; LMN 2R; LMN2R; MGC9041; PHA; PRO0650
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14739
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Expression Region
1-615aa
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AA Sequence
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
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Molecular Weight
97.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LBR (Lamina-associated protein B receptor) is an integral protein primarily located in the inner nuclear membrane, playing a crucial role in various cellular processes, including nuclear architecture maintenance, chromatin organization, and gene expression regulation. The research on LBR has gained traction due to its involvement in important biological functions and its implications in human diseases, particularly in the context of developmental disorders and certain cancers. Studies have illustrated that LBR is essential for the structuring of the nuclear lamina, which provides mechanical support to the nucleus and is involved in the attachment of chromatin to the nuclear envelope. Mutations in the LBR gene (or its homologs) have been associated with conditions such as Greenberg skeletal dysplasia, highlighting its significance in developmental biology. Additionally, the functional dynamics of LBR within the nuclear environment suggest potential regulatory mechanisms that could influence transcriptional activity and cellular responses to external stimuli. Consequently, understanding the structure and function of LBR and its interaction with other nuclear components could offer insights into not only fundamental cellular mechanisms but also potential therapeutic targets for diseases linked to its dysregulation. As a result, the study of LBR and its recombinant forms has emerged as a vital area of investigation, contributing to broader knowledge in cell biology, molecular genetics, and therapeutic developments.
