Analytical Data
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基因名
MRAS
- Application
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别名
MRAS;RRAS3;Ras-related Protein M-Ras
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14807
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表达区间
1-205aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT HKLQC
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRAS (Molecular Ras Gene Family Member) is a member of the Ras superfamily of small GTPases, which play crucial roles in various cellular processes, including cell proliferation, differentiation, and survival. Research into MRAS has gained momentum due to its distinct functional properties compared to other Ras proteins and its implications in cancer biology. Dysregulation of MRAS has been associated with several malignancies, suggesting that it may serve as a potential therapeutic target. Additionally, MRAS is involved in signaling pathways linked to cell adhesion and migration, making it essential for understanding cancer metastasis. As MRAS interacts with various effectors, including phosphoinositide 3-kinase (PI3K) and Ral guanine nucleotide exchange factors, characterizing its activity and molecular interactions is vital for elucidating its role in oncogenesis. Recent advances in recombinant protein technology have facilitated the production of MRAS, enabling researchers to study its structure, function, and potential as a drug target in greater detail. Understanding MRAS's unique mechanisms may pave the way for novel therapeutic strategies aimed at malignancies where MRAS is implicated, thereby enhancing our ability to develop targeted cancer therapies and improve patient outcomes.
