Analytical Data
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Gene name
Irag1
- Application
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Alternative Names
Irag1；IRAG；JAW1L；MRVI1；Inositol 1.4.5-triphosphate receptor associated 1
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9WUX5
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Expression Region
451-550aa
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AA Sequence
NLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNL
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Molecular Weight
18.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Irag1, or Immunoresponsive gene 1, is a critical protein involved in the modulation of immune responses, particularly in relation to macrophage activation and polarization. Initial discoveries highlighted its role in regulating inflammatory processes and response to pathogens, which positions it as a key player in various immunological diseases. Recent studies have demonstrated that Irag1 can influence the Th1/Th2 balance, thereby affecting the overall adaptive immune response. Understanding the mechanisms underlying Irag1's function can provide insights into its potential as a therapeutic target for inflammatory and autoimmune conditions. Furthermore, due to its presence in various immune cell types, the exploration of Irag1's role may have broad implications, ranging from basic immunology to applied biomedical research. Increasing evidence suggests that Irag1 may also participate in cancer immunity, as its expression can alter tumor-associated immune responses. Thus, research into the recombinant expression and functional analysis of Irag1 could advance our comprehension of immune regulation and open new avenues for therapeutic interventions aimed at enhancing or inhibiting immune responses in disease contexts.
