Analytical Data
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基因名
Irag1
- Application
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别名
Irag1；IRAG；JAW1L；MRVI1；Inositol 1.4.5-triphosphate receptor associated 1
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9WUX5
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表达区间
451-550aa
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氨基酸序列
NLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNL
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分子量
18.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Irag1, or Immunoresponsive gene 1, is a critical protein involved in the modulation of immune responses, particularly in relation to macrophage activation and polarization. Initial discoveries highlighted its role in regulating inflammatory processes and response to pathogens, which positions it as a key player in various immunological diseases. Recent studies have demonstrated that Irag1 can influence the Th1/Th2 balance, thereby affecting the overall adaptive immune response. Understanding the mechanisms underlying Irag1's function can provide insights into its potential as a therapeutic target for inflammatory and autoimmune conditions. Furthermore, due to its presence in various immune cell types, the exploration of Irag1's role may have broad implications, ranging from basic immunology to applied biomedical research. Increasing evidence suggests that Irag1 may also participate in cancer immunity, as its expression can alter tumor-associated immune responses. Thus, research into the recombinant expression and functional analysis of Irag1 could advance our comprehension of immune regulation and open new avenues for therapeutic interventions aimed at enhancing or inhibiting immune responses in disease contexts.
