Analytical Data
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基因名
MPG
- Application
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别名
MPG;AAG;ANPG;MID1;DNA-3-methyladenine glycosylase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29372
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表达区间
1-298aa
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氨基酸序列
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSD AAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLAR AFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMF MKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTL RKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLE PSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQALE HHHHHH
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分子量
34 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of MPG (Mannose-6-Phosphate Receptor Glycoprotein) recombinant proteins has garnered significant attention in the fields of molecular biology and biomedicine. MPG plays a crucial role in the intracellular transport and sorting of lysosomal enzymes, facilitating their delivery to lysosomes through mannose-6-phosphate signaling. This process is vital for maintaining cellular homeostasis and preventing lysosomal storage disorders, which arise from deficiencies in enzyme function. Recent advances in recombinant DNA technology have enabled the expression of MPG proteins in various host systems, such as bacteria, yeast, and mammalian cells, allowing for large-scale production and purification. Researchers aim to elucidate the structural and functional properties of MPG, investigate its interactions with other cellular components, and explore its potential therapeutic applications, particularly in enzyme replacement therapies for lysosomal storage diseases. Moreover, understanding the binding mechanisms and specificity of MPG to its ligands is pivotal for designing targeted drug delivery systems. The ability to produce and manipulate MPG recombinant proteins opens new avenues for research and innovation, highlighting their importance in both basic science and clinical applications.
