Analytical Data
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Gene name
LASS3
- Application
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Alternative Names
CERS3. LASS3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IU89
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Expression Region
57-134aa
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AA Sequence
EKFVASPLAKSFGIKETVRKVTPNTVLENFFKHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQE
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Molecular Weight
34.32 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LASS3 (Lipid Associated Sterol Sensing Domain 3) is part of the LASS (Lipid Acyltransferase) family, which plays a pivotal role in lipid metabolism, particularly in sphingolipid synthesis. Research into LASS3 has gained significance due to its potential implications in various physiological and pathological processes, including cellular signaling, cancer progression, and neurodegenerative diseases. Sphingolipids, as critical components of cell membranes, influence cell behavior, and alterations in their metabolism can lead to disease states. LASS3 specifically has been implicated in promoting tumor cell proliferation and survival, making it a potential target for therapeutic intervention. The study of LASS3 recombinant proteins allows for a better understanding of its enzymatic function and interaction with other cellular pathways. By producing these proteins in vitro, researchers aim to elucidate the molecular mechanisms underlying LASS3's role in sphingolipid metabolism and its broader impact on health and disease. This research holds promise for the development of novel treatments that can modify sphingolipid signaling pathways in diseases linked to LASS3 dysregulation. Understanding the structure and function of LASS3 could ultimately lead to new insights into its role in various biological processes and open avenues for therapeutic strategies in cancer and other lipid-related disorders.
