Analytical Data
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基因名
LASS3
- Application
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别名
CERS3. LASS3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IU89
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表达区间
57-134aa
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氨基酸序列
EKFVASPLAKSFGIKETVRKVTPNTVLENFFKHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQE
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分子量
34.32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LASS3 (Lipid Associated Sterol Sensing Domain 3) is part of the LASS (Lipid Acyltransferase) family, which plays a pivotal role in lipid metabolism, particularly in sphingolipid synthesis. Research into LASS3 has gained significance due to its potential implications in various physiological and pathological processes, including cellular signaling, cancer progression, and neurodegenerative diseases. Sphingolipids, as critical components of cell membranes, influence cell behavior, and alterations in their metabolism can lead to disease states. LASS3 specifically has been implicated in promoting tumor cell proliferation and survival, making it a potential target for therapeutic intervention. The study of LASS3 recombinant proteins allows for a better understanding of its enzymatic function and interaction with other cellular pathways. By producing these proteins in vitro, researchers aim to elucidate the molecular mechanisms underlying LASS3's role in sphingolipid metabolism and its broader impact on health and disease. This research holds promise for the development of novel treatments that can modify sphingolipid signaling pathways in diseases linked to LASS3 dysregulation. Understanding the structure and function of LASS3 could ultimately lead to new insights into its role in various biological processes and open avenues for therapeutic strategies in cancer and other lipid-related disorders.












