Analytical Data
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基因名
LASS1
- Application
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别名
CERS1; LAG1; LASS1; UOG1; Ceramide synthase 1; CerS1; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1; Sphingoid base N-stearoyltransferase CERS1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P27544
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表达区间
1-239aa
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氨基酸序列
MPESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAE
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分子量
54.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LASS1 (Longevity Assurance Homolog 1) is a crucial enzyme belonging to the Longevity Assurance gene family, primarily involved in sphingolipid metabolism. It catalyzes the synthesis of sphinganine, a precursor for various bioactive sphingolipids that play pivotal roles in cellular processes such as proliferation, apoptosis, and differentiation. Research has indicated that LASS1 may be implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Additionally, its function in regulating lipid metabolism suggests a significant role in metabolic diseases and aging. Given these diverse biological functions, the study of LASS1 recombinant proteins is essential for understanding its mechanistic roles in lipid signaling pathways and disease progression. By generating and characterizing LASS1 recombinant proteins, researchers aim to elucidate its structural properties, enzymatic activity, and interaction with other cellular components. This knowledge can pave the way for developing novel strategies in disease intervention, making LASS1 an attractive candidate for further biochemical and pharmacological exploration.
