Analytical Data
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基因名
CACNa1B
- Application
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别名
CACNa1B；CACH5；CACNL1A5；Voltage-dependent N-type calcium channel subunit alpha-1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q00975
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表达区间
全长
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氨基酸序列
full
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分子量
262 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNa1B, a member of the voltage-gated calcium channel family, plays a crucial role in the regulation of calcium influx in excitable tissues, including neurons and muscle cells. It is primarily involved in neurotransmitter release in synapses and muscle contraction mechanisms. Abnormalities in CACNa1B function have been associated with various neurological disorders, cardiac issues, and other pathological conditions. The study of CACNa1B recombinant proteins is essential for understanding its structure-function relationship and the molecular mechanisms underlying its role in cellular signaling pathways. Research has focused on the expression and purification of CACNa1B using recombinant DNA technology, allowing for the analysis of its channel properties and pharmacological profiles. By utilizing techniques such as electrophysiological assays and structural biology methods, scientists aim to elucidate the intricacies of CACNa1B’s functioning, paving the way for potential therapeutic targets in treating diseases linked to calcium signaling dysregulation. Understanding CACNa1B’s behavior at the molecular level not only provides insights into its physiological functions but also aids in the development of drugs aimed at modulating its activity.
