Analytical Data
-
Gene name
CACNa1B
- Application
-
Alternative Names
CACNa1B；CACH5；CACNL1A5；Voltage-dependent N-type calcium channel subunit alpha-1B
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q00975
-
Expression Region
全长
-
AA Sequence
full
-
Molecular Weight
262 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CACNa1B, a member of the voltage-gated calcium channel family, plays a crucial role in the regulation of calcium influx in excitable tissues, including neurons and muscle cells. It is primarily involved in neurotransmitter release in synapses and muscle contraction mechanisms. Abnormalities in CACNa1B function have been associated with various neurological disorders, cardiac issues, and other pathological conditions. The study of CACNa1B recombinant proteins is essential for understanding its structure-function relationship and the molecular mechanisms underlying its role in cellular signaling pathways. Research has focused on the expression and purification of CACNa1B using recombinant DNA technology, allowing for the analysis of its channel properties and pharmacological profiles. By utilizing techniques such as electrophysiological assays and structural biology methods, scientists aim to elucidate the intricacies of CACNa1B’s functioning, paving the way for potential therapeutic targets in treating diseases linked to calcium signaling dysregulation. Understanding CACNa1B’s behavior at the molecular level not only provides insights into its physiological functions but also aids in the development of drugs aimed at modulating its activity.
