Analytical Data
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基因名
L3MBTL3
- Application
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别名
L3MBTL3; H-l(3)mbt-like protein 3; Hl(3)mbt like protein; KIAA1798; l(3)mbt like 3 (Drosophila); l(3)mbt like 3; L(3)mbt like 3 protein; L(3)mbt-like protein 3; L3mbtl3; Lethal(3)malignant brain tumor like 3 protein; Lethal(3)malignant brain tumor-like protein 3; LMBL3_HUMAN; MBT-1; MBT1; RP11-73O6.1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96JM7
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表达区间
1-755aa
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氨基酸序列
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADNKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
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分子量
112.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
L3MBTL3, a member of the L3MBTL family of proteins, has gained significant attention in recent years due to its role in epigenetic regulation and its involvement in various biological processes. This protein is characterized by multiple MBT (malignant brain tumor) domains, which allow it to interact with methylated histones and thus influence chromatin structure and gene expression. Research has shown that L3MBTL3 is implicated in cellular differentiation, proliferation, and DNA damage response, making it a key player in maintaining cellular homeostasis. Additionally, abnormalities in L3MBTL3 expression have been linked to several types of cancer, highlighting its potential as a therapeutic target. As scientists delve deeper into the mechanistic pathways involving L3MBTL3, understanding its exact functions and interactions within the epigenetic landscape could unveil novel strategies for cancer treatment and foster insight into the complexities of gene regulation. Furthermore, leveraging advanced techniques such as CRISPR and proteomics, researchers are aiming to unravel the detailed biological roles of L3MBTL3 in both normal and pathological states, paving the way for innovative approaches in the field of oncology and epigenetics.
