Analytical Data
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基因名
CACNa1S
- Application
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别名
CACNa1S；SH3 and cysteine-rich domain-containing Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13698
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表达区间
全长
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氨基酸序列
full
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分子量
212 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The CACNA1S gene encodes the alpha-1 subunit of the L-type voltage-gated calcium channels, which play a crucial role in the excitation-contraction coupling in skeletal muscle cells. Mutations in CACNA1S can lead to various pathological conditions, including hypokalemic periodic paralysis and malignant hyperthermia, making it a significant target for research in neuromuscular diseases and pharmacological studies. Understanding the structure and function of the CACNA1S protein is essential for elucidating the molecular mechanisms underlying these disorders and developing potential therapeutic strategies. The recombinant expression of CACNA1S protein allows for detailed biochemical and biophysical characterization, facilitating the study of its ion channel properties, interaction with regulatory proteins, and response to pharmacological agents. Such studies are vital for advancing our knowledge of calcium channel physiology and pathophysiology, ultimately contributing to improved diagnosis and treatment of associated diseases. Additionally, recombinant CACNA1S proteins serve as valuable tools in drug discovery, particularly in screening compounds that can modulate channel activity for therapeutic benefit.
