Analytical Data
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基因名
KRTHA6
- Application
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别名
HA6; Hair keratin; Hair keratin; type I Ha6; HHA6 ; HKA6 ; K36; Keratin; Keratin hair acidic 6; Keratin type I cuticular Ha6; keratin; hair; acidic; 6; Keratin; hard; type I; Keratin; hard; type I; 6; keratin; type I cuticular Ha6; Keratin-36; Krt36; KRT36_HUMAN; KRTHA6; type I cuticular Ha6; type I Ha6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O76013
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表达区间
1-417aa
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氨基酸序列
MLRSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL
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分子量
73.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTHA6, a member of the keratin gene family, encodes a type II keratin predominantly expressed in the human epidermis. Research on KRTHA6 has garnered interest due to its critical role in skin structure and function, particularly in maintaining keratinocyte integrity and promoting wound healing. Mutations in keratin genes are known to be associated with various skin disorders, including ichthyosis and epidermolysis bullosa, highlighting the significance of understanding KRTHA6’s structure and function. Recent advances in molecular biology and genetic engineering techniques have facilitated the exploration of KRTHA6 at a molecular level, revealing its interactions with other cellular proteins and its involvement in key signaling pathways. Additionally, KRTHA6 expression patterns in different skin layers and during various developmental stages have been studied, providing insights into its regulatory mechanisms. Investigating the role of KRTHA6 in skin diseases could lead to novel therapeutic strategies aimed at targeting keratin-related pathologies. Overall, the study of KRTHA6 is essential for unraveling the complexities of skin biology and developing interventions for associated disorders.
