Analytical Data
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Gene name
KRTHA6
- Application
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Alternative Names
HA6; Hair keratin; Hair keratin; type I Ha6; HHA6 ; HKA6 ; K36; Keratin; Keratin hair acidic 6; Keratin type I cuticular Ha6; keratin; hair; acidic; 6; Keratin; hard; type I; Keratin; hard; type I; 6; keratin; type I cuticular Ha6; Keratin-36; Krt36; KRT36_HUMAN; KRTHA6; type I cuticular Ha6; type I Ha6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O76013
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Expression Region
1-417aa
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AA Sequence
MLRSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL
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Molecular Weight
73.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KRTHA6, a member of the keratin gene family, encodes a type II keratin predominantly expressed in the human epidermis. Research on KRTHA6 has garnered interest due to its critical role in skin structure and function, particularly in maintaining keratinocyte integrity and promoting wound healing. Mutations in keratin genes are known to be associated with various skin disorders, including ichthyosis and epidermolysis bullosa, highlighting the significance of understanding KRTHA6’s structure and function. Recent advances in molecular biology and genetic engineering techniques have facilitated the exploration of KRTHA6 at a molecular level, revealing its interactions with other cellular proteins and its involvement in key signaling pathways. Additionally, KRTHA6 expression patterns in different skin layers and during various developmental stages have been studied, providing insights into its regulatory mechanisms. Investigating the role of KRTHA6 in skin diseases could lead to novel therapeutic strategies aimed at targeting keratin-related pathologies. Overall, the study of KRTHA6 is essential for unraveling the complexities of skin biology and developing interventions for associated disorders.
