Analytical Data
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基因名
METTL1
- Application
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别名
WDR4;tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBP6
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表达区间
1-276aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMAAETRNVAGAEAPPPQKRYYRQRAHSNPM ADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEF ADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGG FQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTL LAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPV VGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH
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分子量
34 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METTL1 (Methyltransferase-like 1) is an emerging protein with critical roles in various biological processes, including RNA modification and regulation. As a member of the methyltransferase family, METTL1 is primarily involved in the methylation of adenosine residues in ribosomal RNA, which is essential for ribosome biogenesis and function. Its dysfunction has been implicated in several diseases, including cancer, where altered RNA methylation patterns may contribute to tumorigenesis. The need for METTL1 recombinant protein arises in the context of understanding its structure-function relationship and elucidating its role in cellular metabolism and gene expression. Given its potential as a therapeutic target, investigators are keen to produce and characterize METTL1 to explore its enzymatic activity, interaction with RNA substrates, and its regulatory mechanisms in various pathways. Thus, the production of METTL1 recombinant protein provides a vital tool for both basic research and potential therapeutic applications, further advancing our understanding of epitranscriptomics.
