Analytical Data
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基因名
PDL2
- Application
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别名
PDL2；B7DC；CD273；PDCD1L2；Programmed cell death 1 ligand 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQ51
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表达区间
20-220aa
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氨基酸序列
LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPH RERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKV KASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRT PEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHP T
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDL2 (Programmed Death Ligand 2) is a crucial member of the PD-1/PD-L pathway, which plays a significant role in the regulation of immune responses. This pathway is integral to the body's ability to maintain self-tolerance and prevent autoimmunity, as well as to modulate immune responses during infections and tumorigenesis. Recent studies have highlighted PDL2's potential as a therapeutic target in cancer immunotherapy, given its role in tumor immune evasion. The expression of PDL2 on various immune cells and tumor tissues has prompted extensive research into its mechanisms of action and interaction with the PD-1 receptor on T cells. Furthermore, recombinant PDL2 proteins have garnered attention as tools for studying these interactions, providing insights into its structure-function relationships and aiding in the development of PDL2-based therapies. As the field of immunotherapy continues to evolve, understanding the biological significance of PDL2 and its recombinant forms could lead to novel strategies for enhancing anti-tumor immunity and improving patient outcomes.
