Analytical Data
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基因名
KRTAP11-1
- Application
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别名
KRTAP11-1; KAP11.1; KRTAP11.1Keratin-associated protein 11-1; High sulfur keratin-associated protein 11.1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IUC1
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表达区间
1-163aa
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氨基酸序列
MSFNCSTRNCSSRPIGGRCIVPVAQVTTTSTTDADCLGGICLPSSFQTGSWLLDHCQETCCEPTACQPTCYRRTSCVSNPCQVTCSRQTTCISNPCSTTYSRPLTFVSSGCQPLGGISSVCQPVGGISTVCQPVGGVSTVCQPACGVSRTYQQSCVSSCRRTC
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTAP11-1, a member of the keratin-associated protein (KAP) family, is primarily expressed in skin and hair follicles, playing a crucial role in the structural integrity and functional properties of hair and the epidermis. Research into KRTAP11-1 has gained attention due to its potential involvement in various dermatological conditions, such as alopecia and other hair disorders, where alterations in keratin composition can lead to structural abnormalities. The protein is believed to contribute to the mechanical resilience and chemical stability of keratin fibers, influencing traits like hair texture and strength. Furthermore, understanding the molecular mechanisms of KRTAP11-1's function can provide insights into hair growth cycles and the development of therapeutic strategies for hair loss and skin diseases. Advances in recombinant protein technology enable the production of KRTAP11-1 for functional studies, facilitating the exploration of its interactions with keratin and other cellular components. This research not only highlights the significance of KRTAP11-1 in dermatology but also opens avenues for novel treatments that target the molecular basis of hair and skin disorders.
