Analytical Data
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Gene name
KRT36
- Application
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Alternative Names
HA6; Hair keratin; Hair keratin; type I Ha6; HHA6 ; HKA6 ; K36; Keratin; Keratin hair acidic 6; Keratin type I cuticular Ha6; keratin; hair; acidic; 6; Keratin; hard; type I; Keratin; hard; type I; 6; keratin; type I cuticular Ha6; Keratin-36; Krt36; KRT36_HUMAN; KRTHA6; type I cuticular Ha6; type I Ha6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O76013
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Expression Region
1-417aa
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AA Sequence
MLRSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL
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Molecular Weight
73.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT36, a member of the keratin family, is an important structural protein that primarily expresses in the epidermis and plays a crucial role in skin integrity and function. The study of KRT36 is driven by its potential implications in dermatological conditions, wound healing, and skin cancers. Abnormal expression or mutations in keratin genes, including KRT36, have been linked to various skin disorders such as keratoderma and alopecia, highlighting the need for a deeper understanding of its biological functions. Researchers have increasingly focused on implementing recombinant protein technology to produce KRT36, allowing for detailed analysis of its structure, function, and interactions. By using techniques such as gene cloning and protein expression systems, scientists aim to explore the mechanistic pathways involving KRT36 and its potential as a biomarker for skin health. Recombinant KRT36 can also be utilized in drug development, protein therapy, and skin regeneration strategies, making it a significant target in both basic and applied biomedical research. This growing interest is part of a broader initiative to develop novel therapeutic approaches to treat skin conditions, emphasizing the importance of elucidating keratin biology in health and disease contexts.
