Analytical Data
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Gene name
Ptger4
- Application
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Alternative Names
Ptger4；PTGER2；Prostaglandin E2 receptor EP4 subtype
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35408
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Expression Region
1-488aa
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AA Sequence
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
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Molecular Weight
53.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on PTGER4 recombinant protein primarily revolves around its role in mediating the effects of prostaglandin E2 (PGE2) in various physiological and pathological processes. PTGER4, also known as the E-prostanoid 4 receptor, is one of the four prostaglandin E receptors and is critically involved in modulating immune responses, pain sensation, and inflammation. Increased expression of PTGER4 has been implicated in various diseases, including cancer, where it may contribute to tumor growth and metastasis by promoting angiogenesis and immune evasion. The investigation of PTGER4 as a therapeutic target has gained traction due to its potential to influence these disease processes. To better understand its functions and therapeutic potential, researchers generate recombinant PTGER4 protein for biochemical assays, structural studies, and screening of small compounds. This enables detailed analyses of receptor interactions, signaling pathways, and the development of targeted therapies aimed at modulating PTGER4 activity. By elucidating the mechanisms through which PTGER4 influences cellular responses, scientists aim to provide insights into novel treatment strategies for diseases associated with dysregulated prostaglandin signaling.
