Analytical Data
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基因名
IkBz
- Application
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别名
IkBz；IKBZ；INAP；MAIL；NF-kappa-B inhibitor zeta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BYH8
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表达区间
1-718aa
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氨基酸序列
MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL NPVVVPQSSP AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES ENIANPMQTS SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP FSNMGNPMNT TQLGKSLFQW QVEQEESKLA NISQDQFLSK DADGDTFLHI AVAQGRRALS YVLARKMNAL HMLDIKEHNG QSAFQVAVAA NQHLIVQDLV NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN QFVDLEATNY DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN TALHVAASLQ YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE QIRRILKGKS IQQRAPPY
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分子量
78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IκBζ (IkBz) is a member of the IκB protein family, which plays a pivotal role in the regulation of nuclear factor kappa B (NF-κB) signaling. This signaling pathway is crucial for various cellular processes, including immune responses, inflammation, and cell proliferation. Unlike other IκB proteins that primarily function as inhibitors of NF-κB, IκBζ has unique properties that allow it to both inhibit and activate NF-κB-dependent gene expression, making it an essential player in the fine-tuning of inflammatory responses. Research on IκBζ has gained momentum due to its involvement in various pathological conditions, such as autoimmunity, cancer, and chronic inflammatory diseases. Its expression is often induced by inflammatory cytokines, linking it to the regulation of genes involved in the inflammatory process. Given its dual role in NF-κB signaling, understanding the mechanisms by which IκBζ is regulated and the context in which it acts is critical for developing targeted therapeutic strategies. Additionally, recent studies have highlighted its potential as a biomarker for certain diseases, further emphasizing the importance of IκBζ in both basic and clinical research. This burgeoning interest in IκBζ is setting the stage for future investigations into its function, regulation, and potential as a therapeutic target in inflammation-related diseases.
