Analytical Data
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Gene name
MAPK11
- Application
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Alternative Names
ZNHIT1;CGBP1;ZNFN4A1;Zinc finger HIT domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15759
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Expression Region
1-364aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMSGPRAGFYRQELNKTVWEVPQRLQGL RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESV EAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAPK11, also known as p38α MAPK, is a serine/threonine kinase that plays a critical role in various cellular processes, including inflammation, differentiation, and stress responses. This protein is a member of the mitogen-activated protein kinase (MAPK) family, which transduces extracellular signals to elicit appropriate cellular responses. Research has shown that MAPK11 is activated by diverse stimuli such as cytokines, growth factors, and environmental stressors. Its dysregulation is implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Consequently, MAPK11 has emerged as a potential therapeutic target, motivating the development of MAPK11 recombinant proteins for functional studies, structural analysis, and high-throughput screening of inhibitors. By generating recombinant MAPK11, researchers can explore its enzymatic activity, identify novel substrates, and elucidate its specific roles in signaling pathways. Furthermore, recombinant MAPK11 can aid in understanding the molecular mechanisms underlying MAPK signaling and its implications in pathophysiology. This research not only provides insights into fundamental cellular processes but also paves the way for the design of MAPK11-targeted therapies, thus holding promise for improving clinical outcomes in diseases linked to aberrant MAPK signaling.
