Analytical Data
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基因名
KLHL6
- Application
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别名
Kelch like protein 6; kelch-like 6; Kelch-like family member 6; Kelch-like protein 6; kelch-like protein KLHL6; KLHL6; KLHL6_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WZ60
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表达区间
1-621aa
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氨基酸序列
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG SVTIRKSYTH IRRIVPGAVS V
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分子量
70.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLHL6, a member of the Kelch-like protein family, plays a significant role in various biological processes, including cell signal transduction, cytoskeletal organization, and the regulation of protein stability through ubiquitin-mediated degradation. Recent studies have highlighted its involvement in several pathological conditions, including cancer, neurodegenerative diseases, and developmental disorders. The understanding of KLHL6's function is crucial as it may serve as a potential biomarker for disease progression and as a therapeutic target. The recombinant expression of KLHL6 protein allows for in-depth analysis of its biological activities, interactions with other proteins, and its role in cellular pathways. Advances in recombinant DNA technology have enabled the production of KLHL6 in heterologous systems, facilitating the elucidation of its structure and function. Moreover, studying the post-translational modifications and specific binding partners of KLHL6 can provide insights into its regulatory mechanisms and potential for therapeutic interventions. Overall, research on KLHL6 recombinant protein is pivotal in advancing our understanding of its multifaceted role in health and disease, paving the way for novel strategies in targeted therapies.
