Analytical Data
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基因名
MAP2K3
- Application
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别名
MAP2K3;MEK3;MKK3;PRKMK3;Dual specificity mitogen-activated Protein kinase kinase 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46734
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表达区间
20-347aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP2K3, also known as MKK3, is a dual-specificity mitogen-activated protein kinase kinase that plays a crucial role in the MAPK signaling pathway, which is involved in various cellular processes, including proliferation, differentiation, and stress responses. Research on MAP2K3 has gained significant attention due to its implications in multiple diseases, particularly in cancer and inflammatory disorders. This protein activates the p38 MAPK pathway, which is critical for mediating responses to environmental stress and inflammatory cytokines. Dysregulation of MAP2K3 signaling has been linked to various pathologies, making it a potential therapeutic target. Moreover, studies have shown that MAP2K3 may influence cell survival and apoptosis, highlighting its role in the cellular response to stimuli. The production of recombinant MAP2K3 protein is essential for detailed functional studies, including its interactions with downstream effectors and upstream regulators, as well as for potential drug screening applications. Understanding the structure-function relationship of MAP2K3 through recombinant approaches can provide valuable insights into its role in health and disease, paving the way for the development of targeted therapies that modulate its activity in pathological conditions. Overall, the study of recombinant MAP2K3 is of great importance in elucidating its biological functions and therapeutic potential in cancer and other diseases.
