Analytical Data
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基因名
MAP1LC3B
- Application
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别名
FUNDC1;FUN14 domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9GZQ8
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表达区间
1-120aa
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氨基酸序列
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
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分子量
18.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP1LC3B, a member of the microtubule-associated proteins family, plays a crucial role in autophagy, a vital cellular process for maintaining homeostasis and responding to stress. This protein is involved in the formation of autophagosomes, structures that encapsulate and degrade damaged organelles and proteins. Research on MAP1LC3B has gained significant attention due to its implications in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Enhanced autophagy mediated by MAP1LC3B has been linked to tumor suppression and prevention of neurodegeneration, while dysregulation of this process can lead to pathological conditions. Moreover, MAP1LC3B is often used as a marker to study autophagy, making it essential for understanding cellular degradation processes. Its role in modulating immune responses also highlights its potential in therapeutic strategies. Recent studies have focused on the functional consequences of different MAP1LC3B isoforms, their interactions with other proteins, and how these dynamics influence the onset of diseases. Overall, MAP1LC3B serves as a pivotal target for research aimed at manipulating autophagy for therapeutic benefit, warranting further exploration of its molecular mechanisms in health and disease.
